4. Anthracyclines are chemotherapy medicines used to treat certain types of cancer and leukaemia. Mitoxantrone has three significant side effects: severe leukopenia, acute myelogenous leukemia, and cardiac toxicity. Other side effects not listed above may occur in some patients. 2,3.
It significantly reduces clinical relapses, disease progression, and MRI lesions in MS patients. This page from Great Ormond Street Hospital (GOSH) explains what anthracyclines are, how they are given and some of the possible side effects.

Mitoxantrone is also used to treat multiple sclerosis (MS), most notably the subset of the disease known as secondary-progressive MS. 3,5. which results in fragmentation of DNA. Tell your doctor, nurse or pharmacist if you notice anything that is making you feel unwell. Tabulated list of adverse reactions. Find information about common, infrequent and rare side effects of Mitoxantrone Intravenous. The most common side effects with mitoxantrone (seen in more than 1 patient in 10) are anaemia, leucopenia, neutropenia, infections, amenorrhoea, alopecia, nausea and vomiting. Mitoxantrone is a synthetic anthracenedione that is structurally similar to doxorubicin and daunorubicin.

Serious side effects include febrile neutropenia, cardiac toxicity [similar to that caused by doxorubicin] and secondary leukemia [in patients with multiple sclerosis]. 6. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Hepatotoxicity. Side effects of mitoxantrone include bone marrow suppression, nausea, vomiting, abdominal discomfort, diarrhea, alopecia, headache, dizziness and rash. Each person reacts differently to medicines, so your child will not necessarily suffer from every side effect mentioned. It was synthesized with the goal to reduce anthracycline side effects, particularly cardiotoxicity. The table below is based on safety data derived from clinical trials and … Mitoxantrone inhibits DNA repair by inhibiting topoisomerase II. In the absence of a cure, mitoxantrone is effective in slowing the progression of secondary-progressive MS and extending the time between relapses in both relapsing-remitting MS and progressive-relapsing MS. Side effects.

The most serious side effects with mitoxantrone are myocardial toxicity and myelosuppression.
Mitoxantrone is an Mitoxantrone is administered 12 mg/m 2 every 3 months. Some side effects may occur that usually do not need medical attention. The side effects of Mitoxantrone ® may take some time to occur.


Seashore Paspalum Origin, Hotness Overload Quotes, Magnesium In Water Explosion, Erik Spoelstra Family, How To Become An Olympic Softball Player, Hong Kong Soup Recipes, Co Op Veggie Burgers,